Abstract: In recent years, the clinical application of the precise molecular targeted therapy and immunotherapy of lung cancer has been a focus of lung cancer research. ⁸F-FDG PET/CT is an imaging technology that merges morphology and molecular metabolism. ¹⁸F-FDG PET/CT can provide timely information about the activities of tumor cells compared with traditional imaging technologies, such as CT and MRI, and has significant value on guiding precise radio-chemotherapy and monitoring treatment efficacy in lung cancer. This article will focus on the application of ⁸F-FDG PET/CT in lung cancer, particularly in the delineation of targeted lesion, evaluation of treatment effect, and prognosis evaluation.