Abstract: Inflammation plays a significant role in the defense against invasive pathogens and injuries. This process helps in tissue repair and elimination of harmful pathogens. However, over or extended inflammatory reaction is harmful to normal cells. Numerous clinical and scientific studies have explored an ideal inflammatory imaging method. Radionuclide imaging can reveal the degree and pathological process of inflammation and prognosticate therapeutic response using instant and highly specific monitoring of leukocyte activation and distribution. This study was performed to provide a brief description of the clinical application and progress in the development of radionuclide probes.