Abstract: Cardiovascular and cerebrovascular diseases are the leading cause of death in China, and the incidence is increasing annually. CT angiography (CTA) examination of cardiovascular and cerebrovascular diseases is gradually extensively used in clinical practice. CTA can observe cardiovascular and cerebrovascular diseases in all directions and clearly shows the anatomical structures and lesions of blood vessels. The traditional cardio-cerebrovascular system is divided into two scans with large radiation dose and complicated operation. Many scholars have studied the simultaneous scanning of cardiac and cerebral vessels with one-step stop imaging in recent years. This method is widely promoted given its advantages, that is, simplicity, fast, noninvasive, low radiation dose, minimal contrast medium, and high accuracy. The author reviewed the research progress of CTA in cardiac and cerebral vascular one-step stop imaging.