18F-FDG PET/CT显像与结直肠癌治疗前分期的相关性研究

Correlation between 18F-FDG PET/CT and pretreatment staging of colorectal cancer

    摘要
  • 摘要:
    目的评价结直肠癌原发灶最大标准化摄取值（SUVmax）与临床病理资料、TNM分期、临床分期的相关性。
    方法回顾性分析83例已确诊的结直肠癌患者资料，所有患者均于治疗前1周内行18F-FDG PET/CT检查，并测量原发灶SUVmax，采用单因素方差分析及两独立样本t检验进行组间比较。采用Spearman相关分析评价SUVmax与TNM分期及临床分期的相关性。
    结果原发灶SUVmax与肿瘤长径（t=2.497，P < 0.05）、病理及分化程度有关（F=3.727，P < 0.05）；不同T分期结直肠癌原发灶的SUVmax差异无统计学意义（F=2.492，P>0.05）；不同N分期、M分期、临床分期结直肠癌原发灶的SUVmax差异有统计学意义（t=2.081、2.168、F=2.839，均P < 0.05）；原发灶SUVmax与T分期无相关性（r=0.004，P>0.05），与N分期、M分期、临床分期呈正相关（r=0.248、0.273、0.324，均P < 0.05）。
    结论结直肠癌原发灶SUVmax与肿瘤长径、病理及分化程度、N分期、M分期、临床分期有关，可反映肿瘤的增殖、侵袭能力。

     

    Abstract:
    ObjectiveTo investigate the correlation between the maximum standardized uptake value(SUVmax) of colorectal cancer primary lesions and clinical pathological features, such as TNM staging and clinical staging.
    MethodsEighty-three patients diagnosed with colorectal cancer and without any previous treatment were retrospectively analyzed and underwent 18F-fluorodeoxyglucose PET/CT examinations within one week, in which the SUVmax of the primary lesions was measured. Data were compared using one-way ANOVA and two-sample t test. Spearman correlation analysis was used to evaluate the correlation of the SUVmax of colorectal cancer primary lesions with TNM staging and clinical staging.
    ResultsThe SUVmax of colorectal cancer primary lesions correlated with the tumor diameter(t=2.497, P < 0.05), pathological type and differentiation degree(F=3.727, P < 0.05). Statistically significant differences were found in the SUVmax of different N stages, M stages, and clinical stages(t=2.081, t=2.168, F=2.839, all P < 0.05) but not in the SUVmax of different T stages. The SUVmax of colorectal cancer primary lesions positively correlated with N, M, and clinical stages(r=0.248, 0.273, 0.324, all P < 0.05) but not with T stages (r=0.004, P>0.05).
    ConclusionsThe SUVmax of colorectal cancer primary lesions correlated with the tumor diameter, pathological type, differentiation degree, N stages, M stages, and clinical stages. Hence, SUVmax can reflect the invasion and proliferation abilities of colorectal cancer.

     

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