Abstract: Myocardial perfusion imaging(MPI) plays an increasingly important role in the diagnosis, risk stratification, and prognosis of coronary heart disease, and coronary artery calcification scoring(CACS) can refine the risk stratification and prognosis of coronary heart disease. However, both methods possess limitations and deficiencies. The combination of CACS and MPI compensates for these deficiencies and provides detailed information to the physician. SPECT/CT generates CT images for attenuation correction when collecting MPI. CACS scans acquired during normal expiration can also be used for attenuation correction. The use of these scans not only reduces the radiological dose but also provides detailed information to the physician. This review focuses on the clinical values of CACS, MPI, and their combination and presents the latest developments in obtaining MPI and CACS images in one scan.