Abstract: Deinococcus radiodurans(DR) has strong resistance to radiation and comprises a series of mechanisms that allow it to survive under various extreme conditions. Some of the genes existing in DR particularly contribute to its robust viability. Two-component system(TCS) is a signal transduction system that widely exists in bacteria. This system can assist the bacteria in coping with the change in external environment and is vital for various life activities. Given that TCS plays an important role in resistance mechanism as a stress response system, this article reviewed the resistant mechanism and the TCS in DR.