Abstract: Intravoxel incoherent motion diffusion-weighted imaging(IVIM-DWI) not only determines various parameters(D value, D^* value, and f value) but also provides diffusion and perfusion information without the contrast agents. IVIM-DWI can show the complexity of the tissue microstructure in a manner more sophisticated than normal and can reflect with high sensitivity the pathological changes of organization. It can confirm the authenticity of the disease. It has become the focus of research in MRI technology in the recent years. Considering data obtained from a large number of local and international studies, we described comprehensively and briefly the basic principle, status, and progress in clinical applications of IVIM-DWI.