Abstract: In recent years, dual-energy myocardial perfusion imaging via dual-source CT has been extensively used in clinical diagnoses and research. This technique can reflect the condition of myocardial microcirculation blood flow, qualitatively and quantitatively evaluate myocardial blood flow, identify myocardial microcirculation and myocardial viability, assess myocardial damage caused by myocardial ischemia, and assess the coronary artery. The sensitivity, specificity, negative predictive value, and positive predictive value of the diagnosis of myocardial damage demonstrated good consistency with pathologic tissue examination. Compared with other techniques, dual-energy myocardial perfusion imaging provides more detailed clinical information. This paper reviews the progress of dual-energy myocardial perfusion imaging via dual-source CT in clinical applications.