植物提取物防治放射性肺损伤的现状与展望

Protective and therapeutic effects of plant extracts on radiation-induced lung injury:present status and future prospects

  • 摘要: 放射性肺损伤(RILI)是放射治疗最为常见的并发症之一, 包括放射性肺炎与放射性肺纤维化。RILI影响患者的生活质量与肿瘤治疗效率。目前临床多采用糖皮质激素、细胞因子抑制剂等治疗RILI, 虽然这些疗法具有一定的疗效, 但均存在较大的不良反应。因此, 寻找高效低毒的RILI防治药物仍是目前亟待解决的问题。近年来, 大量研究表明, 天然的植物提取物在防治RILI方面具有良好的效果, 且不良反应小, 药理作用广泛, 具有潜在的应用和开发价值。笔者综述了近年来RILI防治研究领域中的天然植物提取物及相关进展, 为植物提取物更好地开发应用提供参考。

     

    Abstract: Radiation-induced lung injury(RILI) is a common complication of thoracic radiotherapy, including pneumonitis and the latter fibrosis. It had great impact on long term quality of life and could result in fatal respiratory insufficiency. At present the usual method for it are corticosteroids and cytokine inhibitor. But the side effects of such drugs were also evident. Therefore, identification of safer and more effective radioprotectants for radiation-induced lung injury is urgently required. Fortunately, a great deal of research shows that plant extracts can be great potential for the treatment of RILI. Herein, we review the literature on plant extracts treatment of radiation-induced lung injury. Plant extracts generally have little toxicity and vast pharmacological apllications. This review creates a solid foundation upon which to further study the efficacy of plants that are both currently used as reduce radiation-induced lung injury medicines.

     

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