Abstract: Long non-coding RNAs(lncRNAs) are increasingly involved in diverse biological processes. Upon DNA damage, the DNA damage response(DDR) elicits a complex signaling cascade, which includes the induction of lncRNAs. LncRNA-mediated DDR is involved in non-canonical and canonical manners. DNA-damage induced lncRNAs contribute to the regulation of cell cycle, apoptosis, and DNA repair, thereby playing a key role in maintaining genome stability. This review summarizes the emerging role of lncRNAs in DNA damage and repair.