Abstract:
Objective To compare the diagnostic value of 99Tcm-MIBI SPECT/CT chest imaging combined with X-ray mammography and to investigate their complementarity.
Methods This study included 83 female patients, including those suspected to have breast nodules and those diagnosed with breast cancer. All patients were examined initially via 99Tcm-MIBI chest SPECT/CT imaging and delayed imaging followed by X-ray mammography, and all data were compared with final pathological results.
Results Among the 99Tcm-MIBI imaging results of the 83 female patients, 52 lesions were revealed by delay images(T/NT ratio >3.33). The final criterion for diagnosis was based on positive delay imaging. The T/NT ratio between benign and malignant breast lesions was statistically significant(P < 0.05). The sensitivity, specificity, positive predictive value and negative predictive value of diagnosis via 99Tcm-MIBI SPECT/CT chest imaging were 93.33%, 73.68%, 80.77%, and 90.32%, respectively. The sensitivity, specificity, positive predictive value and negative predictive value of X-ray were 64.44%, 73.68%, 74.36%, 63.63%, respectively. 99Tcm-MIBI imaging superior value to diagnosis X-ray mammogragh for breast cancer(χ2=4.11, P < 0.05), but two methods of consistency spreads(Kappa=0.217, P < 0.05).
Conclusions The sensitivity and specificity of 99Tcm-MIBI were higher than those of X-ray mammography in diagnosis of early-stage breast cancer. 99Tcm-MIBI imaging offers advantages in detecting virus infection aslar-pacific nodules. It is speculated that detecting regular breast nodules and occult lesions can be improved if these two methods are combined because they are complementary techniques.
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