顶空毛细管气相色谱法测定18F-氟代乙酸盐中有机溶剂残留

Determination of residual organic solvents in 18F-FAC by gas chromatography

    摘要
  • 摘要:
    目的 建立以毛细管气相色谱法测定18F-氟代乙酸盐(18F-FAC)中乙腈、丙酮和乙醇3种有机溶剂残留量的方法。
    方法 采用HP-INNOWAX(30 m×0.53 mm, 1 μm)毛细管色谱柱和氢火焰离子化检测器, 检测器温度为270℃, 进样口温度为200℃, 柱温采用程序升温, 载气为氮气, 进样量为1 μl。
    结果 乙腈、丙酮和乙醇均能得到较好的分离, 呈现良好的线性关系, 相关系数分别为:0.9999、0.9973、0.9988, 平均回收率分别为99.8%、101.0%、97.5%, 相对标准偏差值分别为4.6 %、4.0%、1.5%。
    结论 毛细管气相色谱法简便快速、灵敏度高、结果准确可靠, 适用于18F-FAC中残留有机溶剂的测定。

     

    Abstract:
    Objective To develop a method for residual organic solvent determination in 18F-fluoroacetate(18F-FAC) using capillary gas chromatography.
    Methods The residual organic solvents were separated on the HP-INNOWAX capillary chromatographic column using temperature programming. Nitrogen gas was used as the carrier gas, along with a flame ionization detector(FID). The FID and injector temperatures were 270℃ and 200℃, respectively, and the injection volume was 1 μl.
    Results Good linear relationships in the experimental concentrations(r=0.9999, 0.9973, 0.9988) were observed. The three residual organic solvents were separated completely; the average recoveries were 99.8%, 101.0%, and 97.5%, and the relative standard deviation values were 4.6%, 4.0%, and 1.5%, respectively.
    Conclusion The proposed method is simple, rapid, accurate, and highly sensitive, which can be used in detecting residual organic solvents in 18F-FAC.

     

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