SPECT/ CT融合显像对可疑骨转移灶的诊断效能

Diagnostic efficacy of SPECT/CT fusion imaging in assessing possible bone metastases

    摘要
  • 摘要:
    目的 评价SPECT/ CT融合显像对可疑骨转移灶的诊断效能。
    方法 回顾性分析64例恶性肿瘤患者经全身骨显像发现的96个可疑骨转移病灶，对可疑病灶行同机SPECT/CT融合显像，由两名核医学医师分别对SPECT、CT及SPECT/ CT融合显像进行分析并评分，以病理学结果或6个月以上复查影像学及临床随访结果作为最终确诊依据。SPECT/CT融合显像对可疑病灶的诊断效能通过受试者工作特征曲线（ROC曲线）进行评价。
    结果 SPECT/CT显像诊断可疑骨转移灶的灵敏度、特异度、准确率、阳性预测值和阴性预测值分别为93.1%、86.8%、90.6%、91.5%和89.2%；ROC曲线下面积：SPECT/ CT融合图像为0.956，CT图像为0.897，SPECT图像为0.710。
    结论 SPECT/CT融合显像较SPECT及CT显像具有较高的诊断效能。

     

    Abstract:
    Objective To evaluate the diagnostic efficacy of single photon emission computed tomography/computed tomography(SPECT/CT) in assessing possible bone metastases.
    Methods Sixty-four patients with history of primary cancer with 96 lesions that could not be definitively diagnosed using planar scintigraphy were included in this study, and SPECT/CT was performed. SPECT, CT, and SPECT/CT images were independently interpreted and scored by two experienced nuclear medicine physicians. The final diagnosis was confirmed by the pathological results or follow-up(≥6 months). The value of additional fused images was assessed using receiver operating characteristic(ROC) analysis.
    Results The sensitivity, specificity, accuracy, and negative and positive predictive values for SPECT/CT imaging were 93.1%, 86.8%, 90.6%, 91.5%, and 89.2%, respectively. The areas under the ROC curve were 0.956, 0.897, and 0710 for SPECT/CT-fused images, CT images, and SPECT, respectively.
    Conclusion SPECT/CT fusion imaging was more accurate and valuable compared with separate sets of SPECT and CT images.

     

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