Abstract: Hepatocellular carcinoma have high fatality rate and be diagnosed already in middle or late period with other common methods. PET/CT is a new kind of imaging examination technique, as a functional imaging of the molecular level. PET/CT has made certain progress in hepatocellular carcinoma(HCC) diagnosis, prognosis and therapeutic evaluation, which play an increasingly important role in recent years. Combined use of a variety of tracer can improve PET/CT imaging for HCC diagnosis sensitivity and specific degrees. This article aimed to explore the progress on the aspects above reviewed.