11C-蛋氨酸PET/CT显像在脑胶质瘤中的应用价值

Value of 11C-methionine PET/CT imaging in diagnosing cerebral glioma

  • 摘要: 胶质瘤是最常见的颅内原发肿瘤,其病死率及致残率均较高。常规影像学方法在脑胶质瘤的术前分级、预后判断、复发与坏死的鉴别等方面存在一定不足。PET是反映肿瘤生物学特性的一种理想的非侵入性的功能显像方法,而PET/CT则实现了功能代谢图像与解剖形态图像的同机融合,为胶质瘤的诊断提供了功能代谢信息,弥补了常规影像的不足。目前已有多种分子影像途径及示踪剂用于脑胶质瘤的定位诊断及疗效监测。其中,11C-蛋氨酸(MET)PET/CT在脑胶质瘤的诊断、分级、预后评估、浸润范围的勾画、活检计划及放疗计划的制定、放疗后坏死病灶组织和肿瘤复发的鉴别诊断等方面起到重要作用。笔者就近年来11C-MET PET/CT显像在脑胶质瘤中的应用进展做一综述。

     

    Abstract: Cerebral glioma is the most common primary brain tumor with high rates of mortality and morbidity. Conventional imaging methods demonstrate some limitations in preoperative grading, prognostic evaluation, and differentiation between tumor recurrence and radiation necrosis for patients with cerebral gliomas. Positron emission tomography/computed tomography (PET/CT) is an ideal imaging tool for noninvasive examination of underlying tumor biology. Recently, various molecular imaging pathways and tracers for the diagnosis and therapeutic monitoring of gliomas have been studied. 11C-methionine (11C-MET)PET/CT provides various advantages in diagnosing primary gliomas. These benefits include accurate diagnosis, grading, prognosis, assessment of tumor extent, biopsy, radiotherapy planning, and differentiation between radiation necrosis and tumor recurrence. This article provides an overview of the current application of 11C-MET PET/CT in the diagnosis of cerebral gliomas.

     

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