“四物汤”对辐射危害的辅助保护作用研究

Protective activity of Siwu Decoction against radiation hazards Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China

    摘要
  • 摘要:
    目的 研究传统方剂“四物汤”对急性辐射损伤的辅助保护作用。
    方法 根据国家食品药品监督管理总局对抗辐射保健品的规定进行功效评价，包括外周血白细胞数、股骨有核细胞数；检测了小鼠30 d存活率。
    结果 照射后3 d与照射前1 d比较，对照组的白细胞数、红细胞数和血红蛋白量均明显降低；照射后14 d，与对照组比较，低剂量给药组（0.5 g/kg）的白细胞数、红细胞数及血小板数均有升高，差异有统计学意义；小鼠30 d存活率的实验表明，与对照组比较，3个给药组均延长了小鼠的存活天数。
    结论 笔者制备的“四物汤”提取液在推荐剂量对辐射损伤具有辅助保护作用。

     

    Abstract:
    Objective To investigate the protective activity of Siwu Decoction against acute radiation injury.
    Methods The population of peripheral white blood cells(WBCs) and bone marrow nucleated cells, as well as the 30 d survival rate of mice were studied in accordance with the China Food and Drug Administration regulation on anti-radiation health food.
    Results Compared with the control group, mice treated with Siwu Decoction showed significantly increased peripheral WBCs, red blood cells, hemoglobin, platelets, and bone marrow nucleated cells. The 30 d survival rate increased in all administration groups of mice.
    Conclusion Siwu Decoction extract at recommended dose exerts protective activity against radiation injury.

     

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