Abstract: Overexpression of epidermal growth factor receptor(EGFR)has been confirmed to be associated with cell malignancy, metastasis and poor prognosis. Against this target, several drugs have been approvaled, such as gefitinib and erlotinib. However, the therapeutic effect was not satisfied. PET/ SPECT imaging can evaluate the expression and mutation of EGFR at molecular level to provide the basis for individual treat. This article is an overview of the progress of PET/SPECT molecular probes targeting EGFR and related problems in order to provide help for further research.