Abstract: Radiation therapy is one of the important treatments for cancer, but human normal tissue is bound to be caused a certain degree of radiation injury by radiation in the process of radiotherapy. Especially in the process of the treatment of chest cancer and head and neck cancer, radioactive cardiovascular damage seriously affects the quality of life of patients. As the tumor incidence increases year by year, more attention is paid to the study of drugs for prevention and treatment of radioactive cardiovascular damage. This paper summarizes recent progress of drugs for prevention and treatment of radioactive injury of circulation system.