住友CLC模块在线优化合成13N-NH3·H2O的研究

Online optimized synthesis of 13N-NH3·H2O by Sumitomo CLC module

    摘要
  • 摘要:
    目的 确定住友HM-10回旋加速器相关参数，小步优化住友CLC模块，合成显像良好的13N-NH3·H2O。
    方法 优化住友HM-10回旋加速器的束流大小、轰靶时间和靶水中乙醇去自由基含量，提高化学反应效率。用阳离子交换柱（CM柱）吸附靶水和小步优化纯化流程得到高化学纯度的13N-NH3·H2O，并实现一根CM柱上多次吸附纯化（3次左右）。
    结果 用30μA束流轰击10 mmol/L乙醇11 min，合成13N-NH3·H2O 27批次，产量为925 MBq左右，放化纯度和化学纯度均大于99%，注射大狗后心肌灌注显像良好。
    结论 经过回旋加速器锂靶反应条件的优化和住友CLC纯化模块的小步改进能得到产量稳定、显像良好的13N-NH3·H2O，能够满足实验及临床要求。

     

    Abstract:
    Objective To achieve some better 13N-NH3·H2O imaging by confirming the relevant parameters of Sumitomo HM-10 cyclotron and optimizing Sumitomo CLC module.
    Methods Sumitomo HM-10 cyclotron beam size, bombed target time and ethanol content for removing of the radicals were optimized to improve the efficiency of chemical reactions. Using cation exchange column(CM column) to absorb the target water and optimizing the purification process to make high purity 13N-NH3·H2O. Multiple absorbed purification were finished by only one CM column(about 3 times).
    Results After 10 mmol/L ethanol was bombarded by 30 μA beam for 11 min, 27 batches of 13N-NH3·H2O were synthesized, with a yield abou 925 MBq and the radiochemical purity and chemical purity both over 99%. The myocardial perfusion imaging showed a good result when the big dog was injected by 13N-NH3·H2O.
    Conclusions After optimizing cyclotron reaction conditions and micro-step improving Sumitomo CLC purification module, stable yield and better imaging of 13N-NH3·H2O was obtained, which can meet the experimental or clinical requirements.

     

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