Abstract: Breast cancer is one of the most common malignancy which seriously harmful to the women′s health around the world.The application of PET/CT has remarkably improved the management of breast cancer.PET/CT offers advantages in evaluating breast cancer response to therapy and identifying patients who will not respond optimally to preoperative chemotherapy.In recent years, expression of specific molecular markers in breast cancer, such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 status, has direct influence on the prognosis and therapeutic regimen.