Abstract: Alzheimer disease(AD) harms human being′s health seriously.With the development progress of PET molecular imaging, a series of PET positron tracers associated with AD appeard.Among them, pittsburgh compound-B(PIB) and PIB derivatives are studied more deeply and part of them have been used in clinic which are showing great value in diagnosis and therapy of AD.Recently, with the deeper research of AD mechanism, more kinds of PET tracers related to AD are developed, including protein, receptor and peptide radiotracers.This article reviews the current application and research progress of those PET positron tracers which associated with AD.