18F-FDG PET/CT显像中棕色脂肪摄取与室外温度相关性研究

18F-FDG PET/CT: the prevalence of activated brown adipose tissue and outdoor temperature

    摘要
  • 摘要:
    目的 分析18F-FDG PET/CT检查中出现棕色脂肪组织(BAT)摄取与室外温度之间的关系。
    方法 回顾性分析上海长海医院核医学科20 949例受检者的18F-FDG PET/CT图像，并通过PubMed查询2002至2013年间BAT摄取相关研究，收集对应检查日期的检查地区温度，使用一元线性回归分析模型分析BAT摄取发生率(P)与平均室外温度(T)之间的关系。
    结果 PubMed共查询到10项符合标准的相关研究，纳入本研究后(11项研究共44 581例)经简单线性回归分析结果表明，BAT摄取发生率与室外温度呈显著负相关(r=-0.718，P=0.013)，回归方程为P(%)=6.87-0.22×T(℃)，每当气温上升5 ℃，BAT摄取发生率下降约1%。
    结论 BAT摄取发生率比较低，且与平均室外温度呈显著负相关关系。

     

    Abstract:
    Objective To investigate the association between the prevalence of activated brown adipose tissue(BAT)and the average outdoor temperature in 18F-FDG PET/CT.
    Methods 18F-FDG PET/CT scans were performed in 20 949 cases in nuclear medicine department of Changhai hospital and BAT studies from PubMed(2002-2013) were reviewed, and the average outdoor temperatures during the study periods were obtained.A simple linear regression was used to analyze the association between the prevalence of activated BAT(P) and the average outdoor temperature(T).
    Results The review analysis for 11 BAT studies(n=44 581) (including 10 BAT studies from PubMed that meet the criteria for this study) showed a significant negative correlation(r=-0.718, P=0.013) between the prevalence of activated BAT and the average outdoor temperature.The equation of the regression line is P(%)=6.87-0.22×T(℃).The prevalence of activated BAT decreased by about 1% for each 5 ℃ increase in average outdoor temperature.
    Conclusion The prevalence of activated BAT is low in subtropics, there is a significant linear negative correlation between the prevalence of activated BAT and the average outdoor temperature.

     

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