Abstract: Bone is one of the most favorite sites of malignant tumor metastasis, and bone metastasis usually correlates with the prognosis of disease, which leads to the important place of bone scintigraphy in the diagnosis of bone metastasis. Bone scan is widely used in clinical work for its high sensitivity as well as its low cost, revealing bone metabolism and blood flow, and no limitation of metal implantation. Compared with plain bone scan, SPECT/CT bone tomography shows better orientation of lesion, and has higher detection rates and specificity. This article reviews the diagnostic value of malignant tumor bone metastasis.