Abstract: Tumor-like disorders are diseases which are similar to bone tumor in clinical feature, imaging and pathology. Radionuclide bone imaging can display the morphology, blood supply and metabolism of the whole body bone clearly. It can detect abnormal bone metabolism at early stage, and is more sensitive than other imaging examination methods. Imaging data of bone tumor-like disorders are commonly seen in X-ray, CT and MRI at present. This article reviews the diagnostic value in tumor-like disorders by radionuclide bone imaging, which may help clinicians know systematically and improve the diagnosis level.