Abstract: Breast cancer is one of the most common forms of cancer in women. The combination of surgery and radio-chemotherapy is the best treatment for breast cancer nowadays. However, due to heterogeneity of breast cancers, some subtypes of breast cancer, especially the triple negative breast cancer(TNBC), do not respond well to traditional therapy and has relatively poor prognosis. Recent studies indicate that the Wnt/β-catenin signaling pathway, which is particularly over-activated in breast cancer, especially in TNBC, is associated with the occurrence, development, invasion, metastasis and poor prognosis of breast cancer. Inhibition of Wnt/β-catenin signaling can effectively inhibits the growth of breast cancer cells and multidrug resistance in chemotherapy. Furthermore, Wnt/β-catenin signaling is also closely related to radiation resistance. Therefore, with a better understanding of Wnt/β-catenin signaling, it may be a new radio-chemotherapeutic target of breast cancer, especially for TNBC.