分化型甲状腺癌术后131I治疗患者胸腺生理性摄取131I的临床研究

Clinical research on physiological thymic uptake of 131I in post-operative patients with differentiated thyroid cancer

    摘要
  • 摘要:
    目的 探讨分化型甲状腺癌（DTC）术后131I治疗患者胸腺生理性摄取131I的临床特点及131I全身显像（WBS）的影像学特征。
    方法 收集2007年至2013年收治的1882例次DTC术后131I治疗后第3~5天行WBS的患者，分析WBS上纵隔部位有131I摄取，并根据甲状腺球蛋白、甲状腺球蛋白抗体测定、其他影像学检查及临床随访结果最终被证实为胸腺生理性摄取131I的患者资料。
    结果 胸腺生理性摄取131I者共16例，年龄均＜45岁，其中有15例患者至少接受过2次131I治疗，仅有1例第1次131I治疗后胸腺显影; WBS上胸腺生理性摄取131I主要表现为“弥漫性”或“哑铃状”浓聚灶；且胸腺对131I的生理性摄取随重复131I治疗次数的增加而越来越明显。
    结论 胸腺生理性摄取131I是45岁以下DTC术后患者多次131I治疗后WBS假阳性的重要原因之一，充分认识到这一现象并予以鉴别，对于患者下一步的恰当诊治是十分必要的。

     

    Abstract:
    Objective To explore the clinical features and 131I whole body scans(WBS) characteristics of physiological thymic uptake of 131I in post-operative patients with differentiated thyroid cancer(DTC).
    Methods One thousand eight hundred and eighty-two WBS were performed on the 3-5 day after 131I therapy in post-operative patients with DTC between 2007 and 2013. On the basis of thyroglobulin and thyroglobulin antibody measurement, other imaging and clinical follow-up, the mediastinal activity was attributed to physiological thymic uptake of 131I. For such patients, their data were reviewed retrospectively.
    Results Physiological thymic uptake of 131I were confirmed in 16 patients. All of them were under the age of 45. Fifteen patients received at least two therapeutic doses of 131I, and there was only one patient to be found physiological thymic uptake of 131I on the first treatment. The pattern of physiological thymic uptake of 131I was classified as "diffuse" or "dumbbell". Thymic uptake of 131I became more prominent with repeated treatments.
    Conclusions For the next appropriate treatment, it is essential to acknowledge that physiological thymic uptake of 131I in patients with DTC under the age of 45 is an important cause of false-positive WBS.

     

    • HTML全文
    • 参考文献(15)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回