Abstract: Among non-invasive methods for the assessment of ischaemic heart disease, myocardial perfusion imaging(MPI) using SPECT tracers is firmly established and well-known by physician and patients. However, MPI is still affected by several drawbacks such as attenuation due to non-uniform tissue, motion artefacts due to time-consuming scan and radiation exposure. The dedicated solid-state cardiac camera using cadmium zinc telluride(CZT) solid-state detectors emerged in recent years. The camera has gotten more and more attention. The camera has advanced CZT detector, acquisition and reconstruction method. The count rate, spatial resolution and energy resolution of the CZT SPECT have been enhanced significantly. This paper would review the clinical application progress of CZT SPECT.