（N-18F氟甲基）胆碱的合成与质量控制

Synthesis and quality control of 18F-fluoromethyl choline

    摘要
  • 摘要:
    目的 研究（N-18F氟甲基）胆碱（18F-FCH）在日本住友氟碳氮三合一合成装置上的全自动化合成与质量控制。
    方法 由日本住友回旋加速器生产出来的18F-与CH2Br2反应生成中间产物18FCH2Br，在高温下通过Ag-Triflate/C柱对其活性进行改造，生成活性更强的18FC2H4SO3CF3，再与N, N-二甲基乙醇胺在Sep-Pak C-18柱上常温进行反应，分别用酒精、注射用水、生理盐水淋洗串联在一起的Sep-Pak C-18柱和Sep-Pak CM柱后纯化得到成品。通过高效液相色谱法对合成产品的放化纯度进行检测。
    结果 合成产品的放化纯度＞97%，未校正放化收率为27%，合成耗时38 min。
    结论 此种合成方法过程简单、操作容易、产品质量稳定，并且合成效率及放化纯度均有所提高。

     

    Abstract:
    Objective To research the automation synthesis and quality control of 18Ffluoromethyl choline(18F-FCH) by automatic synthesis module from Japanese sumitomo corporation.
    Methods Intermediate product 18FCH2Br was produced by the reaction of CH2Br2 with 18F- which was made by sumitomo cyclotron. 18FC2H4SO3CF3 with a higher activity was generated by modifying the activities of 18FCH2Br through the Ag-Triflate/C column at high temperature. 18FC2H4SO3CF3 reacted with N, N-dimethyl ethanolamine on Sep-Pak C-18 column at room temperature and the products were purified through washing the Sep-Pak C-18 column and Sep-Pak CM column in series with alcohol, water and physiological saline injector respectively. The purity of the final products was detected by high performance liquid chromatography.
    Results The radiochemical purity of 18F-FCH was above 97%, the uncorrected radiochemical yield was 27%, and the synthesis process last for 38 min.
    Conclusion This synthesis method has more advantages, such as easier operation, higher yields, shorter synthesis time, more stable products with a higher radiochemical purity.

     

    • HTML全文
    • 参考文献(9)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回