Abstract: Osteoarthritis(OA) is also called degenerative osteoarthritis, which is often occurring in the elderly. Presently, three kinds of treatments for OA at home and abroad are non-druggery treatment, medication and surgical therapy. But, currently there is no known cure for OA, nor are there effective interventions to change or slow this disease progression. In recent years, there is new recognition about pathogeny, pathogenesis and pathophysiology of OA. Especially it plays more and more important role of the effect of cytokine in the pathogenic process and the diagnosis of OA, and new therapies are coming in succession. This article sums up the therapy and the new progress of the treatment for OA.