Objective To explore the therapeutic effect and complications of operation combined with ¹²⁵I seeds implantation in the treatment of brain glioma.

Methods A retrospective analysis was underwent in 58 cases of recurrent cerebral glioma patients, among them, 23 patients were treated with simple operation, 35 cases were given treatment plans by three-dimensional treatment planning system in preoperation or intraoperation, and according to the does set in intraoperation, ¹²⁵I seeds were implanted in the tumor bed after tumor resection with the prescription dose was 140-188 Gy. Verification and quality evaluation was performed every 2 months by CT or MRI. After 8-32 months follow-up, tumor recurrence rate, survival time and complications were compared between the two groups.

Results There were 20 cases of recurrence in the simple operation group and the recurrence rate was 87%, 3 patients died of postoperative complications. There were 23 cases of recurrence in the intraoperative ¹²⁵I seeds implantation group and the recurrence rate was 65.7%; 5 patients died of postoperative complications, 4 cases of refractory cerebral edema, 3 cases of radiation necrosis of the brain. The recurrence time in intraoperative ¹²⁵I implantation group (97. 5±15. 3)weeks was significantly greater than that in simple operation group(62. 5±13. 6)weeks(t=9. 21, P < 0. 05), the survival time(60. 3±7. 1) weeks was significantly longer than that in simple operation group(43. 1±5. 5) weeks(t=13. 03, P < 0. 05).

Conclusion ¹²⁵I seeds implantation treatment intraoperative could reduce glioma recurrence rate, effectively improve the survival time in recurrent glioma patients.