Abstract: Sleep disorders may affect the health and normal life of human badly. However, the pathophysiology underlying adult sleep disorders is still unclear. Functional neuroimaging can be used to investigate whether sleep disorders are associated with specific changes in brain structure or regional activity. This paper reviews functional brain imaging findings in major intrinsic sleep disorders(i.e., idiopathic insomnia, narcolepsy, and obstructive sleep apnea)and in abnormal motor behavior during sleep(i.e., periodic limb movement disorder and REM sleep behavior disorder). Metabolic/functional investigations(positron emission tomography, single photon emission computed tomography, functional magnetic resonance imaging)are mainly reviewed, as well as neuroanatomical assessments (voxel-based morphometry, magnetic resonance spectroscopy). Meanwhile, here are some brief introduction of different kinds of sleep disorders.