Abstract: Coronary artery calcification score and myocardial perfusion imaging play important role in the diagnosis, risk stratification, prognosis of coronary heart disease. With the emerging of fusion imaging, the combination of CACS and MPI provides more information to the physician. Out of consideration for radiological dose, low-dose non-gated CT has been used to quantitate the coronary artery calcification. This review focuses on the clinical application of coronary artery calcification score, myocardial perfusion imaging and the combination.