两种苯丙烯酸类丹皮酚酯抗辐射作用初探

A preliminary study on anti-radiation effects of two cinnamic paeonol ester compounds

    摘要
  • 摘要:
    目的 观察两种苯丙烯酸类丹皮酚酯化合物——4-甲基苯丙烯酸丹皮酚酯和4-氟苯丙烯酸丹皮酚酯的抗辐射作用。
    方法 以ICR小鼠为研究对象，通过相关脏器系数、白细胞数、血小板数、股骨有核细胞数和股骨骨髓DNA含量等指标，考察两个目标化合物低、中、高剂量下的抗辐射损伤效应。
    结果 与空白对照组比较，4-甲基苯丙烯酸丹皮酚酯和4-氟苯丙烯酸丹皮酚酯均可以提高受照小鼠的骨髓DNA含量和脾结节数、增大脾系数和胸腺系数，并使血小板数得到一定的恢复。
    结论 4-甲基苯丙烯酸丹皮酚酯和4-氟苯丙烯酸丹皮酚酯对小鼠辐射损伤具有一定的保护作用。

     

    Abstract:
    Objective To study the anti-radiation effect of two clinnamic paeonol ester compounds.
    Method The index like white blood cell count, platelet count, bone marrow nucleated cells count, DNA and other organ index on ICR mice were observed to investigate the anti-radiation effect of the two compounds in high, medial and low dosages.
    Results Compared to the control group, the increase of DNA content in marrow, the number of splenic nodules, splenic index and thymus index have been observed in group of 4-methyl cinnamic acid paeonol ester and 4-fluoro cinnamic acid paeonol ester.
    Conclusion 4-methyl cinnamic acid paeonol ester and 4-fluoro cinnamic acid paeonol ester both have the protection effect against radiation damage.

     

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