对甲基桂皮丹酚酯抗辐射活性的研究

白佳利; 于程程; 王德芝; 沈秀; 郝建秀; 王浩; 龙伟; 周则卫

doi:10.3760/cma.j.issn.1673-4114.2013.03.003

对甲基桂皮丹酚酯抗辐射活性的研究

Protective effect of P-methyl cinnamic paeonol esters against radiation damage

摘要

摘要:
目的研究对甲基桂皮丹酚酯的抗辐射活性。
方法以6~8周龄的ICR小鼠作为研究对象，经¹³⁷Cs γ射线一次性全身照射后，以30 d存活率、血液生化指标、脏器指数及肺和肝的超氧化物歧化酶（SOD）、丙二醛为指标，考察低、中、高3个剂量组的对甲基桂皮丹酚酯的抗辐射损伤效应。
结果对甲基桂皮丹酚酯可以提高经8.5 Gy ¹³⁷Cs γ射线一次性全身照射损伤ICR小鼠的30 d存活率，对小鼠经6.5 Gy ¹³⁷Cs γ射线一次性全身照射损伤生理指标影响的检测结果显示，对甲基桂皮丹酚酯在不同程度上提高了血小板和DNA含量、胸腺指数和脾脏指数；且SOD水平随着对甲基桂皮丹酚酯剂量的增加而增加，而丙二醛水平则有所降低，尤其是高剂量组的效果较显著。
结论对甲基桂皮丹酚酯可能具有抗辐射损伤作用。

Abstract:
Objective To study the radiaition protective effect of P-methyl cinnamic paeonol esters on irradiated mice.
Methods ICR mice of age 6-8 weeks were selected as investigated subjects, then the mice whole body were irradiated with 6.5 Gy or 8.5 Gy¹³⁷Cs γ-ray. The 30-day survival rates, organ indexes, superoxide dismutase(SOD)and malondialdehyde levels in lung and liver were observed to evaluate the radiation protective effect of P-methyl cinnamic paeonol esters in high, medium, low dose groups.
Results P-methyl cinnamic paeonol esters increased the 30-day survival rates of 8.5 Gy whole body irradiated mice. And after 6.5 Gy whole body irradiation, P-methyl cinnamic paeonol esters could enhance the platelet counts, DNA levels and thymus, spleen index. Meanwhile, SOD levels were increased with the increasing dose of P-methyl cinnamic paeonol esters, while malondialdehyde levels were decreased, especially in the high dose group.
Conclusion P-methyl cinnamic paeonol esters may play an important role in radiation resistance.

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