Abstract: PET/CT has become a major mean for discriminating benign and malignant tumors, finding the primary tumor, staging, restaging, evaluating the response of treatment, predicting the survivors and guiding the operation, radiotherapy, chemotherapy in adults since it was applied in clinic, but it has been rarely applied in children. There exists some difference between internal and overseas in the application of PET/CT in pediatric malignant tumors based on the relative literatures analysis. It is related to the low level of medical radionuclides knowledge and lack of the knowledge about the application of PET/CT in pediatric malignant tumors, and all of these induce less carry out of the pediatric PET/CT imaging, lack of the experience, eventually form a vicious circle. This article mainly described the above two aspects, in order to promote the application of PET/CT in pediatric malignant tumors.