放射增敏剂尼可胺对Wistar大鼠致畸作用的研究

Study on teratogenicity of Nikean in Wistar rats

    摘要
  • 摘要:
    目的 探讨放射增敏剂尼可胺对Wistar大鼠的致畸毒性。
    方法 将Wistar受孕大鼠随机分为尼可胺高、中、低3个剂量（300、200、100 mg/kg）的给药组以及空白对照组（0.9%氯化钠注射液）。大鼠于孕期第10天按1.0 ml/100 g体质量连续尾静脉注射给药10 d。受孕20 d处死孕鼠，检查母体妊娠与胚胎畸形情况。
    结果 尼可胺各剂量组孕鼠的体质量与空白对照组比较，差异无统计学意义；尼可胺各剂量组均未观察到胎鼠明显的脏器及骨骼的畸形；尼可胺各剂量组雌性和雄性胎鼠活胎体质量、尾长及体长均较空白对照组明显减少和降低。
    结论 尼可胺在受试剂量下存在一定的胎儿毒性，但无明显的致畸作用。

     

    Abstract:
    Objective To investigate the teratogenicity of Nikean in Wistar rats.
    Methods Pregnant rats were divided into 4 groups, three Nikean dosage groups(300, 200, 100 mg/kg) and one negative control group. Nikean or normal saline was given via caudal vein injection for 10 days from the 10 th day of gestation. Pregnant rats were killed at the 20th day of gestation, and parets and their fetuses were examined.
    Results Compared to the control group, there was no difference in weight of pregnant rats in three Nikean dosage groups. No abnormality was observed in skeleton and internal organs of fetuses in three Nikean dosage groups. There were significant differences between three Nikean dosage groups and control group in fetal weight, trunk length and tail length in female and male rats.
    Conclusion NiKeAn at the dose of 300, 200, 100 mg/kg showed a certain fetotoxicity but had no apparent teratogenesis in rats.

     

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