TRAb水平测定在Graves眼病中的临床意义探讨

The clinical value of serum thyrotrophin receptor antibody level in patients with Graves ophthalmopathy

    摘要
  • 摘要:
    目的 探讨血清促甲状腺激素受体抗体（TRAb）在Graves眼病发病机制中的作用。
    方法 选择初发Graves病患者219例，其中，Graves眼病组121例，无Graves眼病组98例，血清检测甲状腺功能、甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TgAb）和TRAb水平，并根据欧洲Graves眼病专家组共识进行Graves眼病临床活动性评分（CAS）和严重程度评估。
    结果 Graves眼病组和非Graves眼病组的血清游离三碘甲状腺原氨酸、游离甲状腺素、TPOAb、TgAb和TRAb水平差异均无统计学意义，TRAb水平与Graves眼病病情的严重程度和CAS之间无相关关系。
    结论 Graves眼病患者的CAS和病情的严重程度与TRAb水平之间不存在相关关系，因此，TRAb水平与Graves眼病的关系还需要进一步研究。

     

    Abstract:
    Objective To explore the value of serum thyrotrophin receptor antibody(TRAb) on the pathological mechanism of Graves ophthalmopathy.
    Methods Two hundred and nineteen newly diagnosed Graves disease patients who were divided into Graves ophthalmopathy group(n=121) and without Graves ophthalmolpathy group(n=98) were tested serum concentration with thyroid function, thyroperoxidase antibodies(TPOAb), thyroglobulin antibodies(TgAb)and TRAb. According to the consensus statement of the European Group on Graves ophthalmopathy, clinical activity score(CAS)and severity evaluation were carried out on Graves ophthalmopathy patients.
    Results There was no significant difference in serum concentration of free thyroxine(FT4), free triiodothyronine(FT3), TPOAb and TRAb between the Graves ophthalmopathy group and the without Graves ophthalmopathy group. Serum concentration of TRAb was not correlated with the severity and CAS of Graves ophthalmopathy.
    Conclusions The CAS and the severity of Graves ophthalmopathy were irrelevant to the serum concentration of TRAb. Therefore, the correlation between TRAb and Graves ophthalmopathy still needs further study.

     

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