昆明-无毛小鼠生物学特性的研究

沈秀; 刘晓秋; 周则卫; 杨福军; 张晓东; 龙伟; 王浩; 洪阁; 徐文清

doi:10.3760/cma.j.issn.1673-4114.2013.02.003

昆明-无毛小鼠生物学特性的研究

Biological characteristic of Kunming-hairless mice

摘要

摘要:
目的观察新品系昆明-无毛小鼠在正常、照射及接种肿瘤情况下的生物学指标。
方法 ① 测定正常昆明小鼠和正常昆明-无毛小鼠的各项生理指标；②将昆明小鼠和昆明-无毛小鼠同时接种上肿瘤（肝癌H22、白血病L1210），观察其生长情况；③昆明小鼠和昆明-无毛小鼠接受¹³⁷Cs源γ射线照射后，观察白细胞、胸腺系数、脾系数等各项生理指标。
结果昆明小鼠与昆明-无毛小鼠正常指标之间无显著差异，只是昆明-无毛小鼠的胸腺略小一些；昆明-无毛小鼠和昆明小鼠接种上两种肿瘤后，肿瘤生长情况均较好；昆明小鼠和昆明-无毛小鼠接受¹³⁷Cs源γ射线照射后，白细胞计数、胸腺系数、脾系数等各项生理指标均明显下降。
结论作为纯系小鼠的昆明-无毛小鼠具备昆明小鼠的生物学特性，可应用于科学实验研究。

Abstract:
Objective To observe the biological parameters of the new strain Kunming-hairless mice on the condition of normal, irradiation and tumor-implanting.
Methods ① The physiological parameters of normal Kunming mice and normal Kunming-hairless mice were observed. ②After being inoculated with hepatic carcinoma H22, leukemia L1210, tumor growth of the two kinds of mice was observed. ③White blood cell count, thymus index and spleen index parameters were observed after irradiation by ¹³⁷Cs γ-ray.
Results The differences of normal parameters between Kunming mice and Kunming-hairless mice were not significant, but the immune parameter-thymuses of Kunming-hairless mice were smaller than that of Kunming mice, tumors growth after implantation were quite well in both strain Kunming and Kunming-hairless mice.
Conclusion As pure strain animal, Kunming-hairless mice possesses biological traits of Kunming mice, it can be applied to the sciences experiment.

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