Abstract: Alzheimer disease (AD) is one of the neurodegenerative disorders that deteriorate the life quality of the elderly in China and developed countries. Prevention and treatment of AD are the focal point in the study of brain science. In recent years, the rapid development of medical imaging technology enables us to get functional orientation and structure descrrption of brain noninvasively and provides a substantial basis for studies of cognition, cognitive impairment, and pathogenesis. It also makes such multi-tiered research and trans-subject combination possible. The progress in AD of imaging technology is briefly reviewed in this article.