18F-FDG PET-CT在霍奇金淋巴瘤疗效评价中的临床价值

A preliminary study on clinical value of 18F-FDG PET-CT in evaluation of efficacy of Hodgkin lymphoma

    摘要
  • 摘要:
    目的 探讨18F-FDG PET-CT在霍奇金淋巴瘤(HL)疗效评价中的临床价值。
    方法 回顾性分析31例HL患者化疗后的18F-FDG PET-CT图像资料, 最终结果经病理和临床随访证实, 并与治疗后单纯CT结果进行对比分析, 采用四格表χ2进行差异的显著性检验。
    结果 ① 31例患者共发现病灶145处, 其中恶性94处、良性51处。18F-FDG PET-CT评价HL治疗效果的灵敏度、特异度、阳性预测值、阴性预测值及准确率分别为97.87%、94.12%、96.84%、96.00%和96.55%, 均明显优于单纯CT检查(χ2=9.83、13.49、11.50、11.69、22.58, P均＜0.05)。②31例患者经PET-CT显像后, 16例(51.61%)更改治疗方案。
    结论 18F-FDG PET-CT是HL疗效监测的有效手段。

     

    Abstract:
    Objective To explore the clinical value of 18F-FDG PET-CT in the evaluation of efficacy of Hodgkin lymphoma(HL).
    Methods Thirty-one cases of post-treatment patients with HL were studied retrospectively. 18F-FDG PET-CT images after chemotherapy were compared with CT post-therapy results. The final diagnosis was based on pathology or clinical follow-ups.
    Results ① A total of 94 malignant lesions and 51 benign lesions were found in 31 patients in the study. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18F-FDG PET-CT in the evaluation of efficacy of HL were 97.87%, 94.12%, 96.84%, 96.00% and 96.55% respectively, which were significantly superior to CT examination alone(χ2=9.83, 13.49, 11.50, 11.69, 22.58, all P < 0.05). ②According to the results of PET-CT, therapeutic schedules of 16 cases(51.61%)had been changed.
    Conclusion 18F-FDG PET-CT is an effective method in the evaluation of efficacy of HL.

     

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