Abstract: CT is a convenient, safe, quick and non-invasive examination which can clearly show the anatomical relationship among different transverse sections and specific tissue structures in brain. Since the mid 70s of last century, the application of CT in brain disease has given people a deeper insight into central nervous system diseases. This article introduces the application and advantages of CT in brain diseases from aspects such as ischemic cerebral infarction, intracranial hemorrhage, brain neoplasms and head injuries.