125I粒子永久性组织间植入治疗浅表恶性转移肿瘤

Interstitial permanent implantation of 125I seeds as salvage therapy for superficial metastatic tumor

    摘要
  • 摘要:
    目的 探讨125I粒子术中组织间植入治疗浅表恶性转移肿瘤的临床效果。
    方法 在B超引导下将125I粒子植入24例恶性肿瘤切除后28处浅表转移病灶肿瘤组织内，治疗1个月后观察疼痛缓解情况和瘤灶大小等变化，并定期随访。
    结果 24例患者术后均恢复良好，未因植入125I粒子而导致严重并发症，随访1~14个月，中位随访8个月，均无不良反应发生。125I粒子植入1个月后，肿瘤病灶疼痛症状完全缓解23处，部分缓解5处；肿瘤病灶体积部分缓解25处，3处无改变。
    结论 125I粒子组织间植入治疗浅表恶性转移肿瘤，方法简便，近期疗效确切，能缓解癌性疼痛及局部压迫等症状，提高患者的生存质量。

     

    Abstract:
    Objective To investigate the clinical effect of 125I seeds interstitial permanent implant for superficial metastatic tumor.
    Methods Under the guidance of the B-ultrasonography, 125I seeds were implanted into 28 units of the superficial metastatic tumor in 24 patients who had been given tumor resection, and the pain relief and tumor size were observed by means of B-ultrasonography and CT regularly after 1 month.
    Results All the patients were followed-up for 1-14 months, and the median length of follow-up was 8 months. The symptoms recovered well with no adverse reaction after operation. One month after the implantation, the pain symptom was alleviated entirely in 23 lesions and partly in 5 lesions. The tumor size shrank in 25 lesions and there was no change in 3 lesions.
    Conclusion Radioactive 125I seeds interstitial permanent implantation is a simple, safe, effective method which can improve living quality of patients and ease the pain and local compression.

     

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