Abstract: This article discussed on the relationship between single nucleotide polymorphism of DNA repair gene human 8-oxoguanine DNA glycosylase (hOGG1) and genetic susceptibility of cancer in aspects of gene structure, biological function and relationship with disease; reviewed molecular epidemiology studies of hOGG1 and cancer genetic susceptibility; figured out the diagnosis and prevention value of hOGG1 as a biomarker of cancer susceptible populations.