Abstract: Research of multimodal imaging probes has become the most popular tendency with the development of fused instruments.But the optimum ratio about sensitivity of various functional probes have become a tough problem to really implement multimodal imaging.As nanomaterials have advantages of tiny volume and plastic physico-chemical characteristics, when it is use to connect, modify, match various probes, it has greater flexibility.Now, it have become the new favor on the research of multimodal imaging probes and made a greater progress.This review mainly described property, application, progress of nanomaterials in multimodal imaging probes.