Abstract: Pancreatic cancer is one of the common malignant tumors in the digestive system, which has poor prognosis and low of 5-years survival rate, so for the early diagnosis of pancreatic cancer is extremely important.¹⁸F-FDG PET-CT imaging system combines the functional and anatomical imaging in one, it not only to reflect the metabolism of tumor tissue, hyperplasia of the level, but also to reflect the anatomy of the tumor and surrounding tissue relationship.¹⁸F-FDG PET-CT has its advantages for the diagnosis of pancreatic cancer, differential diagnosis, staging and prognosis.This review focuses on¹⁸F-FDG PET-CT for the clinicalapplication of pancreatic cancer.