Abstract: The incidence of hepatocellular carcinoma which threatens our health and life seriously ranks third in all the tumors in developing countries.Though most of the disease can be diagnosed by traditional imaging method such as CT, MRI, ultrasonography, for primary hepatocellular cartinoma that diagnoses hard with triditional method, PET-CT can be used as an effective supplement methods.The positive rate of ¹⁸F-FDG PET-CT in diagnosis of primary hepatocarcinoma was low.But when combined with ¹¹C-acetate PETCT, the sensitivity and accurary of ¹⁸F-FDGPET-CT in diagnosis of primary hepatocarcinoma could be improved.