Abstract: ¹⁸F-FDG is generally used for tumors’PET, and it is the most and widest useful positron radiopharmaceutical in the clinic.But it does not have enough sensitivity and specificity for some kinds of tumors.¹¹C-acetate has different distribution in body and uptaken mechanism by cell from¹⁸F-FDG.Many studies have confirmed that¹¹C-acetate has the potential value to make up the insufficiency of¹⁸F-FDG.The researches on¹¹C-acetate PET or PET-CT are reviewed in this paper, including the mechanism, research area and the newest progress.