125I粒子植入治疗脊椎转移瘤的临床价值

Value of CT guided 125I seeds implantation for vertebra metastasis

    摘要
  • 摘要:
    目的 探讨125I粒子植入治疗脊椎转移瘤的初步疗效。
    方法 对15例转移瘤患者的22处病灶于术前制订125I粒子植入计划，确定粒子数量和分布。在CT引导下植入125I粒子，治疗后3~6个月观察疼痛缓解情况和瘤灶大小变化。
    结果 22处脊椎和椎旁转移瘤植入粒子后，疼痛完全缓解（0级）14处，部分缓解（Ⅰ级）6处，轻微缓解（Ⅱ级）2处，总有效率为90.9%（u=5.41，P < 0.001）；脊椎和椎旁转移瘤的瘤灶大小变化：4处完全缓解，12处部分缓解，6处病变稳定，局部控制率为72.7%。
    结论 CT引导下125I粒子植入治疗脊椎转移瘤是一种安全、微创、疗效好的方法。

     

    Abstract:
    Objective To evaluate the clinical value of 125I seeds implantation for vertebra metastasis.
    Methods By CT guide, 125I seeds were implanted in 22 vertebra metastasis of 15 patients.3-6 months later, pain and metastasis biggest diameter were observed to judge therapeutic effect.
    Results In 22 spinal and paraspinal metastases after implantation of particles, complete remission of pain(0 grade)14, partial remission (Ⅰgrade)6, a slight relief(Ⅱgrade)2, the total effective rate was 90.9%(u=5.41, P < 0.001).Change of spinal and paraspinal metastases size: 4 complete remission, 12 partial response, 6 stable disease, local control rate was 72.7%.
    Conclusion CT guided 125I seed implantation in vertebra metastasis is safe, minimally invasive, and possesses a high efficacy.

     

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