Abstract: As one of the most important tracer for PET-CT, the preparation of ¹⁸F-FDG by nucleophilic substitutionis better than electrophilic substitution, therefore the substitution of the formerfor the latter is imperative.Automatic synthesis module technology has powerful function on the large-scale production of radioactive drugs and widely clinical been used.In recent years the application of new technology in ¹⁸F-FDG synthesis module is very fascinating.The requirement for quality control of ¹⁸F-FDG is tremendously strict, for which the administration way of ¹⁸F-FDG is intravenous injection.The advanced detective methods and the standardization of Good Manufacturing Practice are guarantee to ¹⁸F-FDG quality control.The researches on pharmacokinetics of ¹⁸F-FDG show that the metabolic process accords with three-compartment model after intravenous, which provides a basis for clinical medication.In this paper, we review the ¹⁸F-FDG in detail from the principleof synthesis, craft process, quality control, metabolic distributionandclinicalapplication andso on.