Abstract: The main ingredient of ⁹⁹Tc-methylenediphosphonate(⁹⁹Tc-MDP) is chelates which formed by the technetium ⁹⁹Tc after stannous reduction and methylenediphosphonate.Studies have shown that ⁹⁹Tc-MDP can inhibit the inflammatory response, play anti-inflammatory, anti-rheumatic effect, it also have significant analgesic effect by inhibit prostaglandin synthesis.In addition, ⁹⁹Tc-MDP also can regulate the body's own immune and bone metabolism to treat the corresponding diseases.Treating rheumatoid arthritis, ankylosing spondylitis, Graves'ophthalmopathy and other autoimmune diseases.Italso has a good effect on pain which is caused by cancer, femoral head necrosis and osteoporosis.Review progress of ⁹⁹Tc-MDP in clinical applications.